Marquand Chapel was located at the western end of the long path that stretched from Witherspoon past Whig, Clio, and Murray. This placement at the end of this axis assured that religious images would never be far from the minds of the students.

Marquand Chapel burned to the ground in 1920 when sparks from the fire that destroyed Dickinson Hall ignited the Chapel's wooden beams. Although students applauded the loss of Dickinson, they mourned the loss of Marquand Chapel. As the New York Sun editorialized, "Though somewhat out of keeping with its surroundings, [Marquand Chapel] was itself in good taste and its loss will occasion unalloyed regret."